Inhaled salbutamol: a new form of drug abuse?

In day 1 cow colostrum neutralising antibody titres to human rotavirus ranged from 400 to 6400 while the IgA and IgG content was 23-170 mg/dl and 1500-4200 mg/dl, respectively. Both titres and Ig concentrations were lower in colostrum from days 2 and 3. Market milk contained little IgA or IgG and few neutralising antibodies. Because the human jejunum contains 200 Ilg/ml trypsin we treated colostrum samples with trypsin (100-800 fg/ml) for 1 h at 37 °C: rotavirus neutralising titres were not affected. In the therapeutic trial rota colostrum had no effect on duration of diarrhoea, bowel movements, or virus shedding in stool. However, there were no side-effects of rota colostrum-in particular, no milk allergy. 6 orphans were given 20 ml rota colostrum (titre 400-1280) every morning. Of the 9 controls, given 20 ml of market milk, 2, who had had diarrhoea in 1981, were already seropositive for rotavirus and were excluded from the statistical analysis. In Tsuruoka city, sporadic cases of acute gastroenteritis were reported in midDecember, 1982, so rota colostrum (or milk) prophylaxis was started in the orphanage on Dec 14. On Jan 26 there was an outbreak of rotavirus diarrhoea at the orphanage, affecting 6 of the 7 controls